While poisonous, their venom hasn’t reportedly killed anyone yet. Not many lizards are actually poisonous, interestingly enough. They’re the largest lizards indigenous to the U.S., weighing in at about five pounds. They actually only feed a handful of times a year so I wonder how big they’d be if they ate more regularly. When they do feed though, they can eat up to a third of their bodyweight. That’s a fair amount of food. Also, they’re protection status is threatened.